The most impactful header for modern sites is Content Security Policy (CSP). It limits where scripts, styles, and other resources can load from. OWASP recommends starting with a restrictive policy and using Report-Only mode to test. Even a minimal CSP helps reduce the blast radius of script injection.
If you can’t set headers directly (some static hosts are limited), you can still use a CSP meta tag for basic control. It’s not as strong as an HTTP header, but it’s a reasonable improvement for simple sites.
Other small wins include setting a strict Referrer-Policy and disabling MIME sniffing with X-Content-Type-Options. Together these reduce data leakage and make browsers behave predictably.